韩渊怀，男，1963年12月生于山西省原平市。山西农业大学农学院教授、博士生导师、山西省首批131领军人才、山西省学术技术带头人、山西省新兴产业领军人才。主要从事谷子功能基因组学及分子育种研究，植物分子生物学/基因工程教学。中国工程院Engineering Agriculture (原Frontiers of Agricultural Science & Engineering)期刊编委；

1985年毕业于山西农业大学农学院，同年留校任教。1994年赴英留学，2000年获英国Bath大学分子生物学博士学位，之后在英国诺丁汉大学工作。2010年全职回到山西农业大学农学院工作。

承担本科生的《专业英语》、《基因工程》、《科技创新》、《生物科技英语》等课程，硕博士生的《植物基因工程》、《基因组学》、《基因调控研究进展》、《作物基因工程原理与技术》等课程。

科研概述:

在英国诺丁汉大学Grierson教授（英皇家学会院士、中国工程院外籍院士）实验室工作期间（94-95），发现了转基因反向重复基因顺序引起高频高强度基因沉默，受到学术界广泛重视，包括被《Cell》、《Plant Cell》等引用。之后又首次阐明了siRNA与靶基因mRNA降解的直接关系，论文被收入Faculty of 1000并被《Science》等重要杂志引用。

自2010年回国以来,从事谷子等杂粮品质形成机理研究与分子育种。本人先后承担5项国家自然科学基金项目（包括1项区域创新重点项目）。带领团队共获批40项国家自然科学基金项目、7项国家重点研发课题和子课题，代表性论文发表在Nature Plants和Molecular Plant等刊物，创制了一批杂粮新型种质，包括矮杆分蘖优质谷子品系、富集类胡萝卜素-叶酸-黄酮功能谷子品系、早熟矮杆优质谷子品系。

主持科研项目:

1.杂粮作物高产与营养品质形成的分子机制(32241038),国家自然科学基金杂粮专项，350万元，2023-2026

2.生态环境对谷子品质的影响及其机制（U21A20216），国家自然科学基金区域创新发展联合基金重点支持项目，256万元，2022-2025

3.谷子籽粒脂肪含量全基因组关联分析及优异等位变异发掘（32170397），国家自然科学基金面上项目，58万元，2022-2025

4.名优谷子品种晋谷21优异米质基因发掘及其功能研究（31371693），国家自然科学基金面上项目，82万元，2014-2017

5.谷子杂种优势利用及基于全基因组SNP的技术开发，山西省重点研发项目，2017，60万元。

6.谷子功能基因组大数据信息平台，中央引导地方科技发展专项资金，2019，150万元

7.山西省重点研发计划（现代农业领域）项目，富含功能成分的小麦、谷子种质鉴选及栽培技术研究，2022,110万，2022ZDYF108

Liang Y, Han Y.（2024）Pan-genome brings opportunities to revitalize the ancient crop foxtail millet.Plant Commun.5(1):100735. doi: 10.1016/j.xplc.2023.100735.

Huo Yiqiong; Pang Xiangdong; Feng Huixia; Hao Ruili; Zhang Ruijie; Wang Yushen; Wang Haigang; Zhang Bin; Han Yuanhuai ; Effect of Ultraviolet B radiation on the biosynthesis of carotenoids in foxtail millet grains, Agriculture, 2024, 14(2): 289.

Niu H, Han YH*, Ping JA*, Wang YB, Lv X, Chu JQ. (2022) Genome wide association analysis of acid detergent fiber content of 206 forage sorghum (Sorghum bicolor (L.) Moench) accessions. Genetic Resources and Crop Evolution.69:1941–1951

Liu X, Yang Y, Hou S, Men Y, Han Y*(2022)Theintegration ofgenome-wideassociationstudy andhomologyanalysis toexplore thegenomicregions andcandidategenes forpanicle-relatedtraits in foxtail millet.International Journal of Molecular Sciences. 23(23):14735. doi: 10.3390/ijms232314735.

Li XK, Gao J, Song J, Guo K, Hou S, Wang X, He Q, Zhang Y, Zhang Y, Yang Y, Tang J, Wang H, Persson S, Huang M, Xu L, Zhong L, Li D, Liu Y, Wu H*, Diao XM*, Chen P*, Wang XW*, Han YH*(2022)Multi-omics analyses of 398 foxtail millet accessions reveal genomic regions associated with domestication, metabolite traits, and anti-inflammatory effects.Molecular Plant. 15(8):1367-1383.

Tang J, Li X, Zhang Y, Yang Y, Sun R, Li Y, Gao J, Han Y*(2022)Differential Flavonoids and Carotenoids Profiles in Grains of Six Poaceae Crops.Foods. 11(14):2068. doi: 10.3390/foods11142068.

Li H, Han SL, Huo YQ, Ma GF, Sun ZX, Li HY, Hou SY*, Han YH*(2022)Comparative metabolomic and transcriptomic analysis reveals a coexpression network of the carotenoid metabolism pathway in the panicle of Setaria italica. BMC Plant Biology, 22:105.

Sun ZX,Wang XF, RH Liu, Du W, Ma MC,Han YH, Li HY, Liu LL and Hou SY (2021) Comparative transcriptomic analysis reveals the regulatory mechanism of the gibberellic acid pathway of Tartary buckwheat (Fagopyrum tataricum (L.) Gaertn.) dwarf mutants. BMC Plant Biology. doi.org/10.1186/s 12870-021-02978-8

Hou SY, Man XX, Lian BY, Ma GF, Sun ZX, Han LD, Yan LF, Gao H, Du Wei, Wang XF, Zhang YJ, Li HY, Han YH* (2021) Folate metabolic profiling and expression of folate metabolism-related genes during panicle development in foxtail millet (Setaria italica (L.) P. Beauv). Journal of the Science of Food and Agriculture. 102: 268-279. doi: 10.1002/jsfa.11355

Zhang YK, Gao JH, Qie QR, YangYL, Hou SY, Wang XC, Li XK*, Han YH*. (2021) Comparative analysis of flavonoid metabolites in foxtail millet (Setaria italica) with different eating quality. Life, 11(6):578.

Yang ZR, Zhang HS, Li XK, Shen HM, Gao JH, Hou SY, Zhang B, Sean M, Malcolm B, Ma JX, Wu CY, Sui Y*, Han YH*, Wang XC* (2020) A mini foxtail millet with an Arabidopsis-like life cycle as a C4 model system. Nature Plants, 6:1167-1178.

Liu L, Kong W, He L, Wang Y, Zhang Y, Ma M, Han YH* (2019) Volatile profiles from traditional Chinese oat meal varied significantly from oat porridge and differed with cultivars and locations. Journal of Food Science. 84 (9): 2432-2400.

Zhang B, Liu J, Cheng L, Zhang YY, Hou SY, Sun ZX, Li HY, Han YH* (2019) Carotenoid composition and expression of biosynthetic genes in yellow and white foxtail millet [Setaria italica (L.) Beauv]. Journal of Cereal Science. 82: 84-90.

Zhang YR, Yang N, Fray RG, Fisk I, Liu CJ, Li HY, Han YH* (2018) Characterization of volatile aroma compounds after in-vial cooking of foxtail millet porridge with gas chromatography-mass spectrometry. Journal of Cereal Science. 82:8-15.

Hou SY, Sun ZX, Linghu B, Xu DM, Wu B, Zhang B, Wang XC, Han YH, Zhang LJ, Qiao ZJ, Li HY* (2016) Genetic diversity of buckwheat cultivars (Fagopyrum tartaricum gaertn.) assessed with SSR markers developed from genome survey sequences. Plant Molecular Biology Reporter. 34:233–241.

Li W, Tang S, Zhang S, Shan JG, Tang CJ, Chen QN, Jia GQ, Han YH, Zhi H and Diao XM (2016) Gene mapping and functional analysis of the novel leaf color gene SiYGL1 in foxtail millet [Setaria italica (L.) P. Beauv]. Physiologia Plantarum. DOI: 10.1111/ppl.12405.

He L, Zhang B, Wang XC, Li HY, Han YH* (2015) Foxtail millet: nutritional and eating quality, and prospects for genetic improvement. Frontier in Agriculture Science and Engineering. 2(2):124-133.

Hou S, Sun Z, Linghu B, Wang Y, Huang K, Xu D and Han Y* (2015) Regeneration of buckwheat plantlets from hypocotyl and the influence of exogenous hormones on rutin content and rutin biosynthetic gene expression in vitro. Plant Cell, Tissue and Organ Culture, 120(3): 1159-1167.

Li P, Han X, Zong Y, Li H, Lin E* and Han Y*, Hao X* (2015) Effects of free-air CO2 enrichment (FACE) on the uptake and utilization of N, P and K in Vigna radiate. Ecosystems & Environment, 202: 120-125.

Wang XC*, Yang ZR, Wang M, Meng LZ，Jiang YW* and Han Y* (2014) The BRANCHING ENZYME1 gene, encoding a glycoside hydrolase family 13 protein, is required for in vitro plant regeneration in Arabidopsis. Plant Cell Tissue and Organ Culture. 117:279-291.

Hao X, Li P, Feng Y, Han X, Gao J，Lin ED*, Han YH* (2013) Effects of fully open-air [CO2] elevation on leaf photosynthesis and ultrastructure of Isatis indigotica Fort. Plos One, Doi: 10.1371/journal.pone.0074600.

Han YH and Grierson D (2008) Enhancement of post-transcriptional gene silencing by grafting. Plant Signaling & Behavior, 3(1) 30-33.

Shaharuddin N, Han YH（共1）, Li HY, Grierson D (2006) The mechanism of graft transmission of sense and antisense gene silencing in tomato plants. FEBS Letters, 580(28-29):6579-86.

Han YH, Griffiths A, Li HY, Grierson D (2004) The effect of endogenous mRNA levels on co-suppression in tomato. FEBS Letters, 563(1-3): 123-128.

Han YH, Grierson D (2002) Relationship between small antisense RNAs and aberrant RNAs associated with sense transgene mediated gene silencing in tomato. The Plant Journal, 29(4): 509-519 (收入Faculty of 1000，被《Science》杂志较大篇幅引用).

Han YH，Grierson D (2002) The influence of inverted repeats on the production of small antisense RNAs involved in gene silencing. Molecular Genetics and Genomics, 267: 629-635.

Hamilton AJ, Brown S, Han YH, Ishizuka M, Lowe A, Solis AA, Grierson D (1998) A transgene with repeated DNA causes high frequency, post-transcriptional suppression of ACC-oxidase gene expression in tomato. The Plant Journal, 15(6): 737-746.